Curriculum Vitae

Maria Paola Costi

Address:
Dipartimento di Scienze Farmaceutiche
Università degli Studi di Modena e Reggio Emilia
Via Campi 183 - 41100 Modena - Italy.
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Phone number +39-059-205-5134/5125
Fax number +39-059-205-5131
E-Mail costimp@unimore.it

Actual position:

2000- Associate Professor in Medicinal Chemistry, Faculty of Pharmacy, University of Modena and Reggio Emilia, Italy.
Teaching courses in the past five years: Analytical chemistry, Advanced methodologies in drug design, Drug design and new approaches to drug synthesis, Pharmaceutical biotecnology, Combinatorial chemistry and drug discovery, Biopharmaceutical chemisty, Advanced methodologies in pharmaceutical chemistry.

Education & prev. positions:

1993-1998 Researcher in Medicinal Chemistry, Faculty of Pharmacy, University of Modena and Reggio Emilia, Italy.

1990-1992 Temporary Research position in Medicinal Chemistry, Faculty of Pharmacy, University of Modena and Reggio Emilia, Italy.

1986-1989 Doctorate degree in Medicinal Chemistry (PhD), Milan University, Italy. Dissertation on "Synthesis and studies on the electronic structure and biological activity of uracil derivatives".

1985 Graduate degree in Pharmacy, University of Modena, Italy.

1984 Graduate degree in Pharmaceutical Chemistry and Technology, University of Modena, Italy.

Related Experiences:

1996 Short term visiting scientist, Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), USA. "Thymidylate synthase inhibition" Prof. Daniel V. Santi.

1994 Short term visiting scientist, Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), USA. "Structure function studies on Thymidylate synthase: human Thymidylate synthase" Prof. Daniel V. Santi.

1992-1993 Visiting scientist, Department of Phramaceutical Science, University of Ferrara, Italy. "Synthetic approach to N-alkyl derivatives of uridine and cytidine nucleotides" Prof. P. Baraldi, Prof. S. Manfredini.

1991 Visiting scientist (Italian CNR grant), Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), USA. "Structure function studies on Thymidylate synthase" Prof. Daniel V. Santi.

1987 Department of Chemistry, University of Modena, Italy. "Theoretical methods in photochemistry and photophysics: uracil derivatives" Prof. I. Baraldi.

Research Interests:
General fields: drug resistance, enzyme inhibitors, antifolate inhibitors structurally unrelated to the folate. Particular attention is given to methodologies in drug design application.

Developing projects:

1) Structure, function and inhibition of Thymidylate synthase.
2) Structure-based drug design of novel b-lactamse inhibitors.
3) New strategy to the design of Pteridine reductase inhibitors against parasitic diseases.

Address:	Dipartimento di Scienze Farmaceutiche Università degli Studi di Modena e Reggio Emilia Via Campi 183 - 41100 Modena - Italy. ------------------------------------------------ Phone number +39-059-205-5134/5125 Fax number +39-059-205-5131 E-Mail costimp@unimore.it
Actual position:	2000- Associate Professor in Medicinal Chemistry, Faculty of Pharmacy, University of Modena and Reggio Emilia, Italy. Teaching courses in the past five years: Analytical chemistry, Advanced methodologies in drug design, Drug design and new approaches to drug synthesis, Pharmaceutical biotecnology, Combinatorial chemistry and drug discovery, Biopharmaceutical chemisty, Advanced methodologies in pharmaceutical chemistry.
Education & prev. positions:	1993-1998 Researcher in Medicinal Chemistry, Faculty of Pharmacy, University of Modena and Reggio Emilia, Italy. 1990-1992 Temporary Research position in Medicinal Chemistry, Faculty of Pharmacy, University of Modena and Reggio Emilia, Italy. 1986-1989 Doctorate degree in Medicinal Chemistry (PhD), Milan University, Italy. Dissertation on "Synthesis and studies on the electronic structure and biological activity of uracil derivatives". 1985 Graduate degree in Pharmacy, University of Modena, Italy. 1984 Graduate degree in Pharmaceutical Chemistry and Technology, University of Modena, Italy.
Related Experiences:	1996 Short term visiting scientist, Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), USA. "Thymidylate synthase inhibition" Prof. Daniel V. Santi. 1994 Short term visiting scientist, Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), USA. "Structure function studies on Thymidylate synthase: human Thymidylate synthase" Prof. Daniel V. Santi. 1992-1993 Visiting scientist, Department of Phramaceutical Science, University of Ferrara, Italy. "Synthetic approach to N-alkyl derivatives of uridine and cytidine nucleotides" Prof. P. Baraldi, Prof. S. Manfredini. 1991 Visiting scientist (Italian CNR grant), Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), USA. "Structure function studies on Thymidylate synthase" Prof. Daniel V. Santi. 1987 Department of Chemistry, University of Modena, Italy. "Theoretical methods in photochemistry and photophysics: uracil derivatives" Prof. I. Baraldi.
Research Interests:	General fields: drug resistance, enzyme inhibitors, antifolate inhibitors structurally unrelated to the folate. Particular attention is given to methodologies in drug design application. Developing projects: 1) Structure, function and inhibition of Thymidylate synthase. 2) Structure-based drug design of novel b-lactamse inhibitors. 3) New strategy to the design of Pteridine reductase inhibitors against parasitic diseases.